APPLICATION OF THE 2-AZAALLYL ANION CYCLOADDITION METHOD TO SYNTHESES OF (+/-)-CRININE AND (-/+)-6-EPICRININE

[摘要] Transmetalation of the (2-azaallyl)stannane 9 with n-BuLi produced the 2-azaallyl anion 12 which underwent an intramolecular cycloaddition with an alkene to give the perhydroindole 10 in 80% yield as a single stereoisomer. Transformation of 10 to 6-epicrinine 2 and crinine 1 was readily accomplished.

[发布日期] 1994-12-05