THE USE OF ORTHO-CHELATING ARENETHIOLATE NONTRANSFERABLE GROUPS IN THE COPPER(I) CATALYZED SELECTIVE ALPHA-SUBSTITUTION OR GAMMA-SUBSTITUTION OF ACYCLIC ALLYLIC SUBSTRATES WITH GRIGNARD-REAGENTS

[摘要] Ortho-amino arenethiolatocopper(I) compounds are excellent catalysts for the cross-coupling reaction of Grignard reagents with acyclic allylic substrates. For example, reaction of n-BuMgI with geranyl acetate in Et(2)O at 0 degrees C yields quantitatively the gamma substitution product, whereas the same reaction in THF at -30 degrees C affords selectively the a substitution product.

[发布日期] 1994-08-08