A facile non-oxidative method for synthesizing 1,3-disubstituted pyrroles from pyrrolidine and aldehydes

[摘要] Reactions of pyrrolidine with 2 equiv of aldehydes without any catalyst in a pressurized vessel at 140-200 degrees C yielded 1,3-disubstituted pyrroles. alpha-Branched aldehydes gave fairly good yields of the corresponding products by this method, which provides a facile non-oxidative procedure for synthesizing 1,3-dialkylpyrroles from inexpensive pyrrolidine and aldehydes. (C) 2007 Elsevier Ltd. All rights reserved.

[发布日期] 2007-12-24