Application of chiral (E)-crotylsilanes in synthesis: The asymmetric synthesis of the C1-C17 polypropionate fragment of rutamycin B.

[摘要] The asymmetric synthesis of the polypropionate fragment of rutamycin B is reported employing chiral allylsilane bond construction methodology for the introduction of six of the nine stereogenic centers. In this paper, the construction of the C3-C12 subunit and its coupling to the aldehyde 12 through a Mukaiyama-type aldol reaction are described. (C) 1997 Published by Elsevier Science Ltd.

[发布日期] 1997-02-24