The first total synthesis of sporiolide B

[摘要] The first total synthesis of natural cytotoxic agent, sporiolide B, is described. D-Xylose was used as the chiral template to pre-control the absolute configuration during the synthesis. Yamaguchi esterification and ring closing metathesis greatly facilitate the target compound accomplishment. (c) 2006 Elsevier Ltd. All rights reserved.

[发布日期] 2006-11-27

[关键词] sporiolide B;macrolide;natural product;xylose;cytotoxic agent