Synthetic approach to enyne and enediyne analogues of anticancer agents

[摘要] The synthesis and the anticancer activity of a new kind of enynes 2 and 3 and enediynes 4, analogues of Combretastatin A-4 1 are reported and discussed. (c) 2005 Elsevier Ltd. All rights reserved.

[发布日期] 2005-12-05

[关键词] combretastatin A-4;enynes;enediynes;tubulin;polymerization;cytotoxicity