Enantioselective synthesis of the C11-C17 segment of soraphen A1α via organoiron methodology

[摘要] The C11-C17 segment of the antifungal agent soraphen A(1alpha) was prepared from glyceraldehyde acetonide in nine steps. The C12 stereocenter is derived from glyceraldehyde, while the C17 stereocenter as introduced by 1,6-asymmetric control via the coordinated Fe(CO)(3). (C) 2002 Published by Elsevier Science Ltd.

[发布日期] 2002-10-21