SYNTHESIS OF NOVEL POLYHYDROXYLATED QUINOLIZIDINES - RING EXPANDED ANALOGS OF GLYCOSIDASE INHIBITORY INDOLIZIDINES

[摘要] Two polyhydroxylated quinolizidines, (1R,2R,3R,9S,9aR)-1,2,3,9-tetrahydroxyquinolizidine 9 and (1R,2R,3R,9R,9aS)-1,2,3,9-tetrahydroxyquinolizidine 10, have been synthesized by the reductive double cyclization of 15 alpha and 15 beta. Quinolizidine 9 can be viewed either as a ring expanded analog of 6-epicastanospermine or of 8-episwainsonine, while 10 is a ring expanded analog of 1,6,8a-triepicastanospermine or of 8a-episwainsonine.

[发布日期] 1993-12-17