Preparation of azidoaryl- and azidoallryloxazoles for click chemistry

[摘要] A series of azidoaryl- and azidoalkyl(diphenyl)oxazole scaffolds were warranted for biofilm inhibition studies. Cyclization of azidoaryl- or azidoalkyl esters of benzoin with ammonium acetate in acetic acid gives 2-azidoaryl- or 2-azidoalkyl-4,5-diphenyloxazoles. The azidoaryl esters are prepared from the corresponding azidocarboxylic acids/acid chlorides while the azidoalkyl esters are prepared from the corresponding haloalkyl esters. (C) 2012 Elsevier Ltd. All rights reserved.

[发布日期] 2012-10-17

[效力级别]  Proceedings Paper

[关键词] Azides;Click chemistry;Oxazoles;Biofilms;Peptidomimetics