Optically active 6-acetyloxy-2H-pyran-3(6H)-one obtained by lipase catalyzed transesterification and esterification

[摘要] Kinetic resolution of 6-acetyloxy-2H-pyran-3(6H)-one (1) is achieved by immobilized lipase PS on Hyflo Super Cell in organic solvents. Transesterification in hexane/n-butanol yields enantiomerically pure R-(-)-6-acetyloxy-2H-pyran-3(6H)-one, whereas esterification of 6-hydroxy-2H-pyran-3(6H)-one (2) with vinyl acetate by immobilized lipase PS gives the S-enantiomer with e.e.'s up to 76%. (C) 1997 Elsevier Science Ltd.

[发布日期] 1997-03-03