A divergent approach to the myriaporones and tedanolide: Enantioselective preparation of the common intermediate

[摘要] The tedanolide and myriaporone classes of natural products represent interesting targets for synthesis because of their structural similarity and biological activity. The asymmetric preparation of a potential common intermediate in the total synthesis of each of these targets is presented. The key step, a Zr-mediated allylation, allows for the efficient preparation of the hydroxypropionate structural unit. (C) 1998 Elsevier Science Ltd. All rights reserved.

[发布日期] 1998-12-17