Asymmetric desymmetrization of meso-vic-diols by carbamoylation catalyzed with a chiral Cu(II) complex

[摘要] Asymmetric desymmetrization of meso-vic-diols was achieved by carbamoylation in the presence of copper triflate and (S,S)-Ph-BOX as a catalyst without any use of bases. The method was successfully applied to asymmetric desymmetrization of five-to eight-membered cyclic meso-vic-diols in high enantioselectivity with up to 93% ee. (c) 2006 Elsevier Ltd. All rights reserved.

[发布日期] 2006-11-27

[关键词] asymmetric desymmetrization;meso-vic-diol;carbamoylation;chiral copper complex