Synthetic studies towards anti-SARS agents:: application of an indium-mediated allylation of α-aminoaldehydes as the key step towards an intermediate

[摘要] AG7088 was identified as a good starting point for modification, leading to an efficient and bio-available inhibitor for the SARS coronavirus main proteinase (SARS-CoV M-pro). Synthesis of intermediate I and analogues proceeded via a highly diastereoselective indium-mediated allylation of alpha-aminoaldehydes. (C) 2004 Elsevier Ltd. All rights reserved.

[发布日期] 2004-12-20

[关键词] anti-SARS agents;AG7088;indium-mediated allylation;diastereoselective