An enantio- and diastereo-controlled synthesis of (-)-neplanocin A and its 2,3-di-epi isomer

[摘要] An enantioselective Pd catalyzed desymmetrization of cis-3,5-dibenzoyloxycyclopent-2-ene combined with a diastereoselective epoxidation provided a common intermediate that can bifurcate to form either (-)-neplanocin A or its 2,3-di-epi isomer. (C) 1997 Elsevier Science Ltd.

[发布日期] 1997-03-10