SYNTHESIS OF NOVEL, HIGHLY POTENT CYCLIC HEXAPEPTIDE ANALOGS OF SOMATOSTATIN - POTENTIAL APPLICATION OF ORTHOGONAL PROTECTION FOR AFFINITY-CHROMATOGRAPHY

[摘要] The syntheses of new cyclic hexapeptides are described. These peptides potently displace [I-125] CGP-23996 (des-Ala1, Gly2-desamino-Cys3[Tyr11]-dicarba3,14 SRIF) from SRIF receptors on AtT-20 cells. Two of these compounds are of potential value for the isolation of SRIF receptors by affinity chromatography. A key feature in the design was the use of orthogonal protection to provide selective covalent bonding to the solid support.

[发布日期] 1991-09-02