Synthesis of chryseno[1,2-b]heteroarenes and phenanthro[1,2-b:8,7-b′] diheteroarenes by an SNAr-anionic cyclization cascade reaction strategy

[摘要] The synthesis of [S]heterophenacenes bearing one or two indole, furan, or thiophene rings is described using an SNAr-anionic cyclization cascade strategy. The convergent reaction sequences furnish chryseno[1,2-b]heteroarenes and phenanthro[1,2-b:8,7-b']-diheteroarenes in only four synthetic steps. The heteroaromatic functionality is selected and installed in the final step of the syntheses from common ortho-fluoro-ethynylarene precursors. (C) 2020 Elsevier Ltd. All rights reserved.

[发布日期] 2020-12-24

[关键词] Phenacene;Heteroarene;SNAr;Cascade;Nucleophilc substitution