Tetra-o-methyl nordihydroguaiaretic acid and Temozolomide work synergistically on Glioblastoma Multiforme tumors

[摘要] Glioblastoma multiforme (GBM) is a grade IV astrocytoma and one of the most malignant brain tumors. GBM responds poorly to the current treatment methods, temozolomide (TMZ) and radiation. Tetra-O-methyl-nordihydroguaiaretic acid (M4N), a global transcription repressor of genes, is potent when used on GBM cell lines. Here, we investigate the effects of M4N in combination with TMZ on GBM cell lines. Cell proliferation measurements and drug combination analyses using different schedules of administration were performed on GBM cell lines. We found that M4N worked synergistically with TMZ to decrease tumor cell proliferation. M4N also induced apoptotic cell death, and our results suggest future clinical applications of M4N in combination with TMZ for GBM treatment.

[发布机构] Johns Hopkins University

[效力级别] tetra-O-methyl nordihydroguaiaretic acid

[关键词] Glioblastoma multiforme;tetra-O-methyl nordihydroguaiaretic acid;Biology