BackgroundHyperadrenocorticism (HAC) is associated with an increased prevalence of hypertension. This study investigated the left ventricular function using two-dimensional speckle-tracking echocardiography (2D-STE) in small breed dogs affected with spontaneous HAC.Age-matched healthy controls (n?=?9), dogs with pituitary-dependent hyperadrenocorticism (PDH, n?=?10), and dogs with adrenal-dependent hyperadrenocorticism (ADH, n?=?9) were included in this study. Conventional echocardiography, global longitudinal and circumferential strain, and strain rate were assessed.ResultsOn group-wise comparison, left ventricular free wall (LVFWd) and interventricular septal thickness in diastole (IVSd) were thickest in the ADH group, followed by the PDH and controls (P?=?0.014 and P?=?0.001, respectively). Neither LVFWd nor IVSd was correlated with systemic blood pressure (P?=?0.238 and P?=?0.113, respectively). The values of all variables derived from the global strain and strain rate in longitudinal and circumferential directions followed the same pattern: highest in the controls, followed by PDH and then ADH (all P?
