A very rare case of pituitary metastasis infiltrating a non-secretory gonadotroph adenoma

[摘要] Pituitary adenomas are the commonest sellar tumours. Pituitary metastases are very rare, with the most commonprimaries being breast and lung cancers. We report the case of an 83-year-old man with a history of breast carcinomawho presented with recent-onset headaches and progressive deterioration of visual acuity. MRI brain showed a largesellar and suprasellar mass compressing the optic chiasm and involving the pituitary stalk. Transsphenoidal debulkingresulted in symptomatic relief and visual recovery. Specimen examination revealed a combination of a gonadotrophpituitary adenoma that was infiltrated by metastatic breast carcinoma. He had no symptoms of diabetes insipidus. He wassubsequently treated with pituitary radiotherapy. This is a very rare presentation of a pituitary mass with mixed pathology.To our knowledge, this is the third description of a breast carcinoma metastasis into a gonadotroph cell pituitaryadenoma.

[学科分类] 血液学