Mycosis fungoides and metabolic syndrome: A hospital-based case-control study

[摘要] Background  Emerging evidence now suggests an association between Mycosis fungoides (MF) and metabolic risk factors. Objective  To investigate a possible association between MF and metabolic syndrome (MetS). Patients and methods  This study was designed as an observational, case-control study. It included thirty MF patients and 39 controls who were assessed for body mass index (BMI), waist circumference, blood pressure, fasting blood glucose, triglycerides (TG), total cholesterol, high and low density lipoproteins, serum leptin level and insulin resistance. Results  Our results revealed that serum leptin level (P=0.029), TG (P=0.004), cholesterol (P=0.001) and LDL (P=0.019), waist circumference in males (P<0.003), hypertension (P=0.039) and frequency of metabolic syndrome (P=0.042), are statistically significantly higher in MF patients than controls. Conclusion  Our results indicate that patients with MF may be at higher risk for metabolic syndrome. Concurrently, screening for metabolic syndrome is recommended for all MF cases for early detection of cardiovascular risk.

[学科分类] 皮肤病学

[关键词] cardiovascular risk;cutaneous T-cell lymphoma;metabolic risk factors;metabolic syndrome;mycosis fungoides