Study of liver X receptor-alpha gene polymorphism (rs2279238) in a sample of Egyptian vitiligo patients

[摘要] Background  Vitiligo is an acquired skin disorder that results from selective destruction of skin melanocytes. It is characterized clinically by the development of depigmented macules and patches. More than 150 genes have been identified to affect the pigmentation of the skin, hair, and eyes. Liver X receptor-α (LXR-α) expression is upregulated in the melanocytes of the perilesional skin as compared with the normal skin of vitiligo patients suggesting its possible contribution in vitiligo pathogenesis. Objective  To study LXR-α gene polymorphism (rs2279238) in a sample of Egyptian vitiligo patients. Patients and methods  T) detection was done by allelic discrimination using fluorogenic 5’ Nuclease assay. Results  LXR-α gene polymorphism was significantly associated with vitiligo among Egyptian patients but is not correlated with either severity or activity of vitiligo. Conclusion  LXR-α gene polymorphism may be associated with vitiligo as found in a sample of Egyptian patients.

[学科分类] 皮肤病学

[关键词] gene polymorphism;liver X receptor alpha;vitiligo