Evaluation of hepatic hemangioma in patients with cherry angioma

[摘要] Background  Cutaneous cherry angioma (CA) and hepatic hemangioma (HH) are the most common types of acquired vascular proliferations that develop during aging process with unknown etiologies. The role of angiogenic and hormonal factors has been proposed in inducing these vascular lesions. Objective  To compare the frequency of HH in persons with and without CA. Patients and methods  This case–control study consisted of 160 patients including 80 patients with CA and 80 patients without CA. Sex, age, history of contraceptive pills intake, number of pregnancies, BMI, number of the CA lesions, and liver ultrasound findings were collected for all participants. Results  HH was detected significantly more frequently in the participants with CA (P<0.001), but there was no significant association between number of CA and number of HH (P=0.837). History of oral contraceptive pill intake was significantly more frequent in women with HH, but this history was not significantly more frequent in women with CA compared with control group. Conclusion  HH was significantly more frequent in participants with CA. Thus, CA may be a cutaneous marker for HH.

[学科分类] 皮肤病学

[关键词] angiogenic factors;cherry angioma;hepatic hemangioma