Analysis of Correlation Structures using Generalized Estimating Equation Approach for Longitudinal Binary Data

[摘要] Summary: Longitudinal binary data often arise in clinical trials when repeated measurements, positive or negative to certain tests, are made on the same subject over time. To account for the serial corre lation within subjects, we propose a marginal logistic model which is implemented using the Generalized Estimating Equation (GEE) ap proach with working correlation matrices adopting some widely used forms. The aim of this paper is to seek some robust working correla tion matrices that give consistently good fit to the data. Model-fit is assessed using the modified expected utility of Walker & Guti´errez Pe˜na (1999). To evaluate the effect of the length of time series and the strength of serial correlation on the robustness of various working correlation matrices, the models are demonstrated using three data sets containing respectively all short time series, all long time series and time series of varying length. We identify factors that affect the choice of robust working correlation matrices and give suggestions under different situations.

[学科分类] 土木及结构工程学

[关键词] Longitudinal data;Serial correlation;Robustness