Representing and decomposing genomic structural variants as balanced integer flows on sequence graphs

[摘要] BackgroundThe study of genomic variation has provided key insights into the functional role of mutations. Predominantly, studies have focused on single nucleotide variants (SNV), which are relatively easy to detect and can be described with rich mathematical models. However, it has been observed that genomes are highly plastic, and that whole regions can be moved, removed or duplicated in bulk. These structural variants (SV) have been shown to have significant impact on phenotype, but their study has been held back by the combinatorial complexity of the underlying models.ResultsWe describe here a general model of structural variation that encompasses both balanced rearrangements and arbitrary copy-number variants (CNV).ConclusionsIn this model, we show that the space of possible evolutionary histories that explain the structural differences between any two genomes can be sampled ergodically.

[发布日期] 2016-09-29

[关键词] Rearrangement;Structural variation;Copy-number variation;DCJ