Bcl-B: an “unknown” protein of the Bcl-2 family

[摘要] Bcl-B is a poorly understood protein of the Bcl-2 family that is highly expressed in many healthy tissues and tumor types. Bcl-B is considered an antiapoptotic protein, but many reports have revealed its contradictory roles in different cancer types. In this mini-review, we elucidate the functions of Bcl-B in normal conditions and various pathologies, its regulation of programmed cell death, its oncogene/oncosuppressor activity in tumorigenesis, its impact on drug-acquired resistance, and possible approaches to inhibit Bcl-B.

[发布日期] 2023-10-23

[关键词] Bcl-B/Bcl-2L10;Bcl-2 family proteins;Carcinogenesis;Programmed cell death;Oogenesis;Embryogenesis