Modeling amyloids in bacteria

[摘要] An increasing number of proteins are being shown to assemble into amyloid structures, self-seeding fibrillar aggregates that may lead to pathological states or play essential biological functions in organisms. Bacterial cell factories have raised as privileged model systems to understand the mechanisms behind amyloid assembly and the cellular fitness cost associated to the formation of these aggregates. In the near future, these bacterial systems will allow implementing high-throughput screening approaches to identify effective modulators of amyloid aggregation.

[发布日期] 2012-12-28

[关键词] Fibril;Amyloidosis;Amyloid Fibril;Amyloid Formation;Yeast Prion