Putting the pH into phosphatidic acid signaling

[摘要] The lipid phosphatidic acid (PA) has important roles in cell signaling and metabolic regulation in all organisms. New evidence indicates that PA also has an unprecedented role as a pH biosensor, coupling changes in pH to intracellular signaling pathways. pH sensing is a property of the phosphomonoester headgroup of PA. A number of other potent signaling lipids also contain headgroups with phosphomonoesters, implying that pH sensing by lipids may be widespread in biology.

[发布日期] 2011-12-02

[关键词] Phosphatidic Acid;Phosphatidic Acid;Intracellular Membrane;Planar Cell Polarity;Anionic Lipid