Cilia, calcium and the basis of left-right asymmetry

[摘要] The clockwise rotation of cilia in the developing mammalian embryo drives a leftward flow of liquid; this genetically regulated biophysical force specifies left-right asymmetry of the mammalian body. How leftward flow is interpreted and information propagated to other tissues is the subject of debate. Four recent papers have shed fresh light on the possible mechanisms.

[发布日期] 2012-12-19

[关键词] Particle Image Velocimetry;Biliary Atresia;Primary Ciliary Dyskinesia;Situs Inversus;Definitive Endoderm