Dietary glycemic index and retinal microvasculature in adults: a cross-sectional study

[摘要] ObjectiveTo analyze the relationship between dietary glycemic index (GI) and retinal microvasculature in adults.MethodsThis was a cross-sectional study of 300 subjects from the EVIDENT II study. Dietary GI was calculated using a validated, semi-quantitative food frequency questionnaire. Retinal photographs were digitized, temporal vessels were measured in an area 0.5–1 disc diameter from the optic disc and arteriolar-venular index (AVI) was estimated with semi-automated software.ResultsAVI showed a significant difference between the tertiles of GI, after adjusting for potential confounders. The lowest AVI values were observed among subjects in the highest tertile of GI, whereas the greatest were found among those in the lowest tertile (estimated marginal mean of 0.738 vs. 0.768, p = 0.014).ConclusionsIn adults, high dietary GI implies lowering AVI values regardless of age, gender and other confounding variables.Trial registrationClinical Trials.gov Identifier: NCT02016014. Registered 9 December 2013.

[发布日期] 2016-10-18

[关键词] Glycemic index;Retinal vessels;Carbohydrates;Microcirculation