Association study of angiotensin converting enzyme gene polymorphism with elderly diabetic hypertension and lipids levels

[摘要] ObjectiveTo investigate the relationship between angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and diabetic essential hypertension in elderly population.MethodsPolymerase chain reaction (PCR) technique was used in 260 elderly normal control patients, 205 elderly hypertensive patients and 138 elderly diabetic hypertensive patients to detect the I/D polymorphism in ACE gene.ResultsDD genotype frequency (0.352) and D allele frequency (0.543) in elderly hypertensive patients were higher than those in the normal control patients. DD genotype (0.421) and D allele frequency (0.579) in elderly diabetic hypertensive patients were significantly higher than those in the control patients (0.133 and 0.250). The differences of DD genotype and D allele frequency between the elderly hypertensive patients and the elderly diabetic hypertensive patients were not significant (P > 0.05).ConclusionACE gene deletion is a risk factor for hypertension but is not a risk factor for diabetes in elderly population.

[发布日期] 2013-12-19

[关键词] Angiotensin converting enzyme gene;Insertion/deletion polymorphism;Elderly;Hypertension;Diabetic hypertension