Investigation of Severity of Lung FibrosisBy Dynamic Modelling Of HumanRespiratory System

[摘要] In this work, the severity of lung fibrosis is assessed by developing an electric model. This model is an electrical analogy to the biological structure of the human respiratory system. The electrical model composes of resistors (R), capacitors (C) and inductors (L). Different computational studies can be carried out by developing a transfer function from this model. This facilitates qualitative investigations and assessment of the various stages of severity of lung fibrosis. Various tools (like state space modelling) have been adopted by us in order to verify the validity of the proposed model. The physiological status of alveoli conditions of the lungs are observed by computing both the time and frequency domain responses. The alveolar compliance of the lungs determines the criticality of pulmonary scarring or fibrosis.

[关键词] fibrosis;respiratory system;electrical mode;time/frequency-domain responses;state-space technique;stability analysis;compliance.