Efficacy of epidermal growth factor receptor targeting in advanced chordoma: case report and literature review

[摘要] BackgroundChordomas are very rare low-grade malignant bone tumors that arise from the embryonic rests of the notochord. They are characterized by slow growth and long history with frequent local relapses, and sometimes metastases. While chemotherapy is not efficient, imatinib has shown antitumor activity.Case presentationWe report on a 76-year-old patient with EGFR-overexpressing advanced chordoma that progressed on imatinib and subsequently responded to erlotinib during 12 months.ConclusionsWe report the fourth case of advanced chordoma treated with an EGFR inhibitor. We also review the literature concerning the rationale and potential of EGFR targeting in chordoma.

[发布日期] 2011-10-04

[关键词] Imatinib;Erlotinib;Chordoma;EGFR Expression;Small Molecule Tyrosine Kinase Inhibitor