Cell-free and intracellular nucleic acids: new non-invasive biomarkers to explore male infertility

[摘要] Male infertility is a devastating problem that affects many couples worldwide. However, the molecular mechanisms and causes of idiopathic male infertility remain unclear. Circulating cell-free nucleic acids have an important role in human physiology and emerging evidence suggests that they play a role in male infertility. This review summarizes recent results on cell-free and intracellular nucleic acids in male infertility and discusses their potential use as biomarkers of male infertility in the clinical practice.

[发布日期] 2017-04-21

[关键词] cf-DNA;cf-mRNA;miRNA;piRNA;Male infertility;Seminal plasma;biomarkers;cf-DNA;cf-mRNA;miRNA;piRNA;Infertilité masculine;Plasma séminal;Biomarqueurs