Selecting appropriate Magnetic Nanoparticles for Hyperthermia

[摘要] Due to immature cells, low blood flow rate, high density and lack of oxygen environment inside the tumour, it is experimentally seen that, tumour cells at temperature between 42°C and 46°C the viability of the cancerous cells is reduced 5,14. Therefore efficiency of chemotherapy and radiation is increased. In recent years due to the development in area of nano technology, magnetic nanoparticle (MNPs) hyperthermia has been deeply studied as a promising new tumour therapy, because in presence of an alternating magnetic field they show remarkable heating effects. In order to achieve efficient and safe operational hyperthermia conditions, it is necessary to study or investigate detail about what heating model or magnetic loss processes dominant over the other in the ensemble of nanoparticles which are injected at the cancerous tumour site. Because there is more than one heat loss process are involved in generating heat by MNPs. First experimental work on magnetic materials for hyperthermia was carried by Gilchrist in 1957. He heated various tissue samples with the help of different sizes of γ-Fe2O3. Since then, there have been numerous theoretical and experimental work has been done by different people on different nanoparticles. Here, in this work we compare theoretical results given by different MNPs .And taking into account cellular uptake mechanism it is showed that at a low frequency of applied magnetic field maghemite and at a high frequency of applied magnetic field FeCo is the best magnetic particle to use for the hyperthermia.

[关键词] Magnetic Nanoparticles (MNPs);Nanoparticles (NPs);Relaxation time;Critical size;Blocking temperature