Langlois Reagent: An Efficient Trifluoromethylation Reagent

[摘要] The fluorine atom has a grand reception in pharmaceutical, material, and agrochemical industries as it dramatically alters the physical, chemical, and metabolic propertiesof organic compounds in its presence. Hence, its incorporation as an atom or fluorine-containing functional groups inorganic molecules remains a huge interest among the organic chemists.1 Among the fluorine-containing functionalgroups, the trifluoromethyl (CF₃) group is the most common group that could improve molecular properties andhence predominantly found in pharmaceutical substances.Therefore, the development of novel methods to build theC–CF₃ bond is of great interest, and several other reagentshave been developed.

[学科分类] 精神健康和精神病学

[关键词] Langlois reagent;trifluoromethylation;free radical;fluoroorganic synthesis;sodium trifluoromethanesulfinate or sodium triflinate