Temperature-Controlled Diastereoselective Doebner/Ugi Tandem Reaction

[摘要] Novel peptidomimetics containing a pyrrolone fragment were synthesized by a tandem combination of Doebner and Ugi type multicomponent reactions with controlled diastereoselectivity. This approach represents a convenient synthesis in the temperature range from 25 to 45 °C. In most cases, the new method allowed each diastereomer to be isolated separately.

[学科分类] 精神健康和精神病学

[关键词] multicomponent reactions;Doebner reaction;Ugi reaction;peptidomimetics;pyrrolones;diastereoselectivity