Palladium-Mediated Reductive Heck Cyclization for the Synthesis of Fused Retinoid Derivatives

[摘要] Linearly fused retinoid derivatives have been synthesized via a straightforward pathway using a palladium-catalyzed reductive Heck cyclization strategy. The synthesis involved a four-step linear approach utilizing iodination, sulfonylation or benzylation or esterification, palladium-catalyzed Sonogashira cross-coupling and palladium-mediated reductive Heck cyclization.

[学科分类] 精神健康和精神病学

[关键词] retinoids;Heck;Sonogashira;cross-coupling