Recent Progress on the [3+2] Cycloaddition Route for the Synthesis of All-Carbon Quaternary Stereocentres

[摘要] Construction of all-carbon quaternary centres is an important task in organic synthesis. In spite of the challenges associated with Csp3–Csp3 bond construction in a sterically constrained environment, significant advances have been made in this area. Among the latter, both catalytic and noncatalytic [3+2] cycloaddition approaches have gained wide attention recently. This short review summarizes the [3+2] cycloaddition reactions reported during the period 2016–2022 for the synthesis of molecules possessing one or more all-carbon quaternary stereocentres.

[学科分类] 精神健康和精神病学

[关键词] all-carbon;quaternary;stereocentres;[3+2] cycloaddition;cyclization