The Synthesis of 5-Hydroxybenzofurans via Tandem In Situ Oxidative Coupling and Cyclization

[摘要] A series of 5-hydroxybenzofurans have been prepared by PIDA-mediated oxidation and coupling cyclization of β-dicarbonyl compounds and hydroquinones. The reaction functionalizes C(sp2)–H of hydroquinones directly with yields of target molecules up to 96%.

[学科分类] 精神健康和精神病学

[关键词] 5-hydroxybenzofurans;oxidation;dearomatization;aromatic C(sp2)–H functionalization;one-pot reaction