Baeyer–Villiger Monooxygenases (BVMOs) as Biocatalysts

[摘要] Natural or artificial enzymes are used in biocatalyticprocesses to produce high-value fine chemicals, most notably chiral pharmaceutical intermediates. On the other hand,there are few instances of the enzymatic production of bulkcompounds.1 In particular production of polymer precursors such as -caprolactone, currently obtained from cyclohexanone utilizing peracetic acid; where Baeyer–Villigermonooxygenases (BVMOs) are potential alternative catalysts to carry out the reaction under much milder conditions.2 Bulk manufacturing of feedstock chemicals utilizingbiocatalysts such as BVMO has yet to be accomplished dueto a number of reasons.3 The versatility of BVMOs is highlighted in this Spotlight, along with various instances ofhow protein engineering has been employed to circumventsome of the disadvantages of BVMO use.

[学科分类] 精神健康和精神病学

[关键词] biocatalyst;Bayer–Villiger monooxygenases;metabolic pathways;biotransformations;regioselectivity