Clinico-Immunohistochemical Analysis of Ovarian Tumors in a South Indian Population: A Single-Center Study

[摘要] Background and objectives: In India, ovarian tumors are the fifth leading cause of death in women. Theyaccount for 6% of all cancers in women. The present study aimed to provide support for a new theory of ovariancarcinogenesis by investigating the frequency of ovarian tumors and determining whether the Ki-67 labelingindex and p53 overexpression help in differentiating borderline and malignant surface epithelial tumors.Methods: The study included all ovarian tumor specimens sent for histopathological examination to theDepartment of Pathology of Narayana Medical College between June 2017 and October 2019.Results: The frequency of benign epithelial and malignant tumors was 85.47% and 11.97%, respectively.Surface epithelial tumors (81.96%) and germ cell tumors (8.54%) were the most common ovarian tumors. Inimmunohistochemistry, p53 overexpression in surface epithelial neoplasms showed moderate positivity in all 2cases of serous carcinomas, while 2 out of 6 mucinous carcinomas cases showed weak positivity. All six casesof mucinous carcinomas showed a Ki-67 labeling index of 26-50%. Serous carcinomas showed a high index of51%, while mucinous carcinomas had a mean index of 37%. Overexpression of Ki-67 was significantly morecommon in malignant surface epithelial neoplasms (41.83%) when compared with borderline epithelialneoplasms (27%) (p<0.001)Conclusion: In comparison to borderline serous and mucinous tumors, Ki-67 overexpression is significantlymore common in malignant surface epithelial tumors. Moreover, p53 overexpression is significantly morecommon in serous carcinoma when compared with borderline serous tumors but not mucinous tumors. Overall,these markers could be beneficial for diagnosing difficult cases and predicting prognosis.

[学科分类] 数学（综合）

[关键词] Ki-67;p53;ovarian carcinoma;Immunohistochemistry