Implications of endodontic treatment in chemo-osteonecrosis of the maxillary jaw due to bisphosphonates. An updated review

[摘要] Introduction: Chemo-osteonecrosis of the jaw can be caused by the pharmacodynamics of bisphosphonates and periapical-pulp physiopathology. Therefore, the objective of this study was to carry out a bibliographic review on endodontic treatment and chemo-osteonecrosis of the jaw and its recommendations. Materials and Methods: An electronic systematic review has been prepared in the PubMed and manual verification from 2005 to 2020, according to the 2020 Prism Guidelines and using inclusion and exclusion criteria, under the terms: “Bisphosphonate AND root canal therapy” and “Bisphosphonate associated osteonecrosis of the jaw AND endodontics.” Results: The 22 selected articles were divided into two differentiated blocks. The first one includes endodontic treatment in patients with bisphosphonate therapy and its relationship with maxillary chemo-osteonecrosis. The second includes recommendations to be followed in patients on bisphosphonate and root canal therapy. Conclusions: Patients who were administered intravenous or intraoral bisphosphonates for more than 4 years with associated risk factors are more predisposed to chemo-osteonecrosis of the jaw. Endodontics is safe compared to other traumatic procedures.

[学科分类] 口腔科学

[关键词] Bisphosphonates;bisphosphonate-related osteonecrosis of the jaw;endodontic treatment;review;root canal therapy