What Else to Pay Attention in Terms of Bone Health Other than Osteoarthritis among Candidates Undergoing Total Knee Replacement: Observations in a Subset of Indian Population

[摘要] Background Earlier it was thought that osteoarthritis and osteoporosis were mutually exclusive but many studies now prove that these diseases coexist. This study was undertaken to assess the bone health in terms of mineral density and other markers among patients undergoing total knee replacement due to osteoarthritis.Methods A total of 100 patients with advanced osteoarthritis undergoing total knee replacement and satisfying inclusion and exclusion criteria were selected. Detailed social, medical, personal, and family history was recorded. All participants underwent for dual-energy X-ray absorptiometry scan (spine and both hips), X-rays (both knees and pelvis), Western Ontario and McMaster Universities osteoarthritis index (WOMAC) scoring, and serum levels of vitamin D, calcium, phosphorus, alkaline phosphatase, and Parathyroid hormone (PTH). Data collected and analyzed.Results In total, 87% of total participants were females. Mean values for age, height, weight, serum vitamin D3, serum PTH, serum calcium, serum phosphorus, serum alkaline phosphatase, WOMAC score, and bone mineral density (BMD) score (T-score) were 65.35 years, 160.15 cm, 69.37 kg, 26.91 ng/mL, 48.02 pg/mL, 9.01 mg/mL, 3.40 ng/mL, 57.91 IU/L, 56.32, and −1.16, respectively.Conclusion Osteopenia and osteoporosis seem prevalent in the Indian population with advanced knee osteoarthritis. Our findings do not support the hypothesis of inverse relation between osteoarthritis and lower BMD. The study reflected poorer bone health and lesser average age for Indian patients undergoing total knee replacement.

[学科分类] 工程和技术（综合）

[关键词] arthroplasty;dual-energy X-ray absorptiometry;osteoarthritis;osteoporosis;parathyroid hormone