Visualizing surface marker expression and intratumoral heterogeneity with SERRS-NPs imaging

[摘要] Cell surface marker expression in tumors dictates the selection of therapeutics, therapy response, and survival. However, biopsies are invasive, sample only a small area of the tumor landscape and may miss significant areas of heterogeneous expression. Here, we investigated the potential of antibody-conjugated surface-enhanced resonance Raman scattering nanoparticles (SERRS-NPs) to depict and quantify high and low tumoral surface marker expression, focusing on the surface markers epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) in an intracerebral and peripheral setting with an inter- and intratumoral comparison of Raman signal intensities.

[学科分类] 大气科学

[关键词] SERRS;Raman imaging;Raman Nanoparticles;Raman Spectroscopy;Brain tumor;Glioblastoma multiforme;Breast Cancer;Breast Cancer Metastasis;Tumor Heterogeneity;Surface marker expression;EGFR;HER2.