Meta-Analysis the Effect of Combination Oral Contraceptive on the Risk of Venous Thromboembolism and Stroke in Family Planning Acceptors

[摘要] Background: The global percentage of contraceptive users in women of reproductive agerange (15-49 years) or women who are marriedis 62.7%. Combined oral contraceptives represent 8.8% of the prevalence (more than 100million women). COCs are very effective inpreventing pregnancy, but like most medications, combined oral contraceptives can beassociated with a variety of side effects andrisks, including venous thromboembolism(VTE) and stroke. This study aims to determinethe estimated effect of combined oral contraceptives on venous thromboembolism andstroke on family planning acceptors by metaanalysis.Subjects and Method: Meta-analyzes wereperformed by searching for articles from theGoogle Scholar, PubMed, Research Gate, Scopus, Springer Link, and Science direct databases. The keywords used in the search for thearticle included “oral contraceptive” OR “combined oral contraceptives” OR “risk factor”AND “venous thrombolism” OR “VTE” AND“stroke” AND “family planning”. The inclusioncriteria in this study were full text articles, from2000-2020, with a case-control study design.The article analysis was carried out usingRevMan 5.3.Results: There are 15 articles analyzed. Theresults showed that combined oral contraceptives increased the incidence of venousthromboembolism and stroke in family planning acceptors (aOR 2.95; 95% CI = 1.80-4.84;p <0.001); (aOR 1.50; 95% CI = 1.30-1.74; p<0.001). The results of the meta-analysisshowed a publication bias between the use ofcombined oral contraceptives and the incidenceof stroke among family planning acceptors.Conclusion: Combined oral contraceptivesaffect venous thromboembolism and stroke infamily planning acceptors.

[学科分类] 食品科学和技术

[关键词] COCs;venous thromboembolism;stroke;family planning acceptors