The Effect of Low Dose of Aspirin on the Preeclampsia in Pregnant Women: A Meta-Analysis

[摘要] Background: In 2020 there were 4,627 maternal deaths in Indonesia. Preeclampsia is a complication in pregnancy that occurs 2-8% of all pregnancies and is a major cause of maternal morbidity.Low-dose aspirin has been shown to be a safe and effective primary prevention for the incidence ofpreeclampsia. With preventive measures can reduce both moral and material losses for patients athigh risk for the incidence of preeclampsia. The purpose of this study was to estimate the magnitudeof the effect of low-dose aspirin on the incidence of preeclampsia in pregnant women based onprevious research.Subjects and Method: This study is a systematic review and meta-analysis. Article searches wereconducted using electronic databases such as Google Scholar, PubMed, Cochrane, Science Direct.The articles used are published articles from 2012-2022. The keywords used to search the articlewere “Aspirin OR Acetylsalicylic Acid AND Prevention AND Pre-Eclampsia OR Toxemia ANDRandomized Controlled Trials”. The inclusion criteria used are articles with randomized control trialstudies, full text articles are available, the results of the analysis used are Risk Ratio. The populationof the study was high-risk pregnant women, the research intervention was the administration of lowdose aspirin, the study comparison was a placebo, and the outcome of the study was preeclampsia,the articles were in English or Indonesian. The article search results are listed in the PRISMAdiagram and analyzed using the Review Manager 5.3 application.Results: A total of 7 articles from China, America, India, Congo, Guatemala, Pakistan, and Finlandshowed that aspirin had an effect of 0.87 times in reducing the incidence of preeclampsia whencompared with placebo or no administration (RR = 0.87; 95% CI 0.72 to 1.05). although notstatistically significant (p=0.160).Conclusion: Low-dose aspirin affects the incidence of preeclampsia in pregnant women.

[学科分类] 食品科学和技术

[关键词] low-dose aspirin;preeclampsia;and pregnant women