Can lessons learned about preventing cardiac muscle death be applied to prevent skeletal muscle death?

[摘要] In 2017, 200 million people worldwide wereliving with disability due to fractures.1 Softtissue damage and prolonged tourniquetapplication as a result of these injuries canlead to limb dysfunction, paralysis, and evenamputation.2 While ischaemia often causes theinitial insult, reperfusion leads to a second-hit,intense inflammatory response that can causemuscle apoptosis and necrosis in what hasbeen termed the ischaemia-reperfusion (IR)injury.3 Other causes of skeletal muscle IR injuryinclude elective or emergent tourniquet use,acute or chronic compartment syndrome, andvascular injury requiring repair.4 PreventingIR injury has been an area of interest in cardiology after myocardial infarction (MI) but hasnot been aggressively pursued in the orthopaedic realm.

[学科分类] 骨科学

[关键词] Glucose-insulin-potassium;Skeletal muscle;Ischaemia-reperfusion