Subchondral physiology and vasculo-mechanical factors in load transmission and osteoarthritis

[摘要] Although the blood supply of bone atrest has been well defined by Brookes andothers,1–3 this was always in static or postmortem tissue. Denham4 and Day et al5recognized that several times body weightwas transferred across joints during activity.Joint surface pressures of many atmosphereshave been measured. While activity appearsto be the primary function of the skeleton,the way in which activity affects perfusionunder joints has received little attention.6,7Intraosseous pressure (IOP) has beenstudied in normal, avascular, and steroidtreated models, but only under static conditions.8-14 IOP has been recorded in associationwith forage decompression for painful andosteonecrotic bone conditions.15,16 Variationin IOP with drugs and on exsanguination hasbeen found.17,18 IOP was thought to be raisedin osteonecrosis, arthritis, and bone pain.However, there has been difficulty in definingnormal IOP and using it effectively for clinicalpurposes.

[学科分类] 骨科学

[关键词] Subchondral;Hydraulic;Physiology;Vessels;Choke valve;MRI;osteoarthritis (OA);physiology;trabeculae;subchondral bone;saline;Orthopaedic surgeons;blood;femoral condyle;animal model