Benefit of sunlight and melatonin on back pain and inflammation

[摘要] Chronic back pain is a common reoccurring issue affecting over 570 million peopleglobally.1 It represents the second leadingcause of disability worldwide, constitutinga major welfare and economic problem.2Traditionally, the notion that the aetiology ofchronic back pain is unknown in the majorityof cases has been erroneously perpetuated.More emphasis has been put on identifying the precise pain generator in chronicback pain, with common causes including:radicular pain, facet joint pain, sacroiliacpain, pain related to lumbar stenosis, anddiscogenic pain.2 Among them, intervertebral disc degeneration is one of the mostcommon identifiable causes of chronic backpain, and previous studies show a clear linkbetween radiological as well as microscopicintervertebral disc (IVD) degeneration andchronic back pain.

[学科分类] 骨科学

[关键词] Chronic back pain;Inflammation;Melatonin;inflammation;back pain;intervertebral disc (IVD);chronic back pain;transforming growth factor beta 1;matrix metalloproteinase 13;interleukin 6;Nuclear Factor-kappaB;intervertebral disc degeneration