Silicone medical adhesive removal for central venous catheter care optimization in patients with hematological diseases

[摘要] Regular manipulations with central venous catheters (CVC) are associated with the risk of medical adhesive-related skin injury (MARSI) and infectious complications. Traditionally, alcohol-containing anti-adhesives are used to remove film dressings, but they may cause skin toxic effects. Meanwhile, the silicone-based anti-adhesives are successfully used in clinical practice, especially in abdominal surgery. In 2021-2022, hematopoietic stem cell transplantation (HSCT) recipients (n=46) with haematology diseases participated in comparative study. The control group (n=26) consisted of patients who used alcohol-containing solution (Ekobriz, Mir Dezinfektsii, Russia) for CVC care, and the comparison group (n=20) was treated with silicone-based spray (Niltac, Convatec, England). A decreased frequency of skin irritation was revealed in the CVC dressing area with silicone-based spray, i.e., 5% versus 30.8% with alcohol-based solution (p=0.03). There were no differences in the frequency of febrile neutropenia, i.e., 70% vs 84.6% (p=0.4); inflammation at CVC entry site, 20% vs 34.6% (p=0.45); sepsis incidence, 35% vs 53.8% (p=0.33), respectively. None of the patients had skin allergy when using Niltac spray. Thus, in a representative group of HSCT patients, the silicone-containing spray proved to be safe and effective in order to reduce the incidence of CVC skin irritation.

[学科分类] 肿瘤学

[关键词] Central venous catheter;film dressing;silicone medical anti-adhesive.